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Liposomal stabilization of camptothecin's lactone ring

✍ Scribed by Burke, Thomas G.; Staubus, Alfred E.; Mishra, A. K.; Malak, Henryk

Book ID
120473416
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
278 KB
Volume
114
Category
Article
ISSN
0002-7863

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Considering the possibility of an in vivo equilibrium 1 + 3a, the "lactonized" neuroleptic 1 is supposed to have quite different pharmakokinetic properties compared to the analogous diphenylbutylpiperidine pimocide. 1 showed little affinity to the 5-HT\*-') but high (Ki = 17 nmolj) to the dopamine D