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A Mechanistic and Kinetic Study of the E-Ring Hydrolysis and Lactonization of a Novel Phosphoryloxymethyl Prodrug of Camptothecin

โœ Scribed by Bradley A. Hanson; Richard L. Schowen; Valentino J. Stella

Book ID
111540828
Publisher
Springer US
Year
2003
Tongue
English
Weight
123 KB
Volume
20
Category
Article
ISSN
0724-8741

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A novel prodrug strategy for ฮฒ-dicarbony
A novel prodrug strategy for ฮฒ-dicarbonyl carbon acids: Syntheses and evaluation of the physicochemical characteristics of C-phosphoryloxymethyl (POM) and phosphoryloxymethyloxymethyl (POMOM) prodrug derivatives
โœ Sundeep S. Dhareshwar; Valentino J. Stella ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 226 KB

The C-phosphoryloxymethyl (POM) and phosphoryloxymethyloxymethyl (POMOM) prodrugs resulting from derivatization at the reactive a-carbon of b-dicarbonyl carbon acid drugs represent a unique approach for improving their chemical stability and aqueous solubility. This work evaluates the physicochemica