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Lipoprotein(a): A kinetic study of its influence on fibrin-dependent plasminogen activation by prourokinase or tissue plasminogen activator

✍ Scribed by Liu, Jian Ning; Harpel, Peter C.; Pannell, Ralph; Gurewich, Victor


Book ID
126489822
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
795 KB
Volume
32
Category
Article
ISSN
0006-2960

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit