TRANSCRIPTIONAL ACTIVATION OF HEME OXYGE
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Satoru Oshiro; Hiroki Takeuchi; Midori Matsumoto; Shun-Ichi Kurata
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Article
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1999
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Elsevier Science
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English
⚖ 874 KB
Heme oxygenase (HO)-1 catalyzes the conversion of heme to biliverdin, iron and carbon monoxide. HO-1 is induced by many reagents including heme, Hb and lipopolysaccharide (LPS). LPS is known to activate the HO-1 gene in cultured mouse liver and macrophage cells through oxidative activation of NF-kap