Lipophosphonate/lipophosphoramidates: A family of synthetic vectors efficient for gene delivery
✍ Scribed by Mathieu Berchel; Tony Le Gall; Hélène Couthon-Gourvès; Jean-Pierre Haelters; Tristan Montier; Patrick Midoux; Pierre Lehn; Paul-Alain Jaffrès
- Book ID
- 116309465
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 686 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0300-9084
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## Background: Efficient and non-toxic gene delivery, preferably with non-viral dna vectors readily transferable to clinical practice, is generally regarded as a major limitation for gene therapy. ## Methods: A 31 amino acid, integrin-targeted bifunctional synthetic peptide (polylysine-molossin),
## Abstract ## Background Non‐viral methods of gene delivery have been an attractive alternative to virus‐based gene therapy. However, the vectors that are currently available have drawbacks limiting their therapeutic application. ## Methods We have developed a self‐assembled non‐viral gene carr