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Lipophilic Di- and Triamides as Ionophores for Alkaline Earth Metal Cations

✍ Scribed by Daniel Erne; Nada Stojanac; Daniel Ammann; Peter Hofstetter; Ernö Pretsch; Wilhelm Simon

Publisher
John Wiley and Sons
Year
1980
Tongue
German
Weight
431 KB
Volume
63
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Different electrically neutral lipophilic di‐ and triamides were prepared and their ion selectivity in membranes studied. In membranes the ionophore N, N′‐diheptyl‐N, N′‐dimethyl‐succinamide prefers Ca^2+^ over Mg^2+^ by a factor of 20 but rejects Na^+^ and K^+^ in respect to Mg^2+^ by a factor of 100 and 10, respectively. This selectivity suffices to perform useful intracellular Mg^2+^ activity studies.

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