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Lipolytic action of 3,3′5-triiodo-l-thyronine, A cyclic AMP phosphodiesterase inhibitor

✍ Scribed by Lewis R. Mandel; Frederick A. Kuehl Jr.


Book ID
118850226
Publisher
Elsevier Science
Year
1967
Tongue
English
Weight
308 KB
Volume
28
Category
Article
ISSN
0006-291X

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A concise synthesis of thyroxine (T4) an
✍ Grzegorz M. Salamonczyk; Vibha B. Oza; Charles J. Sih 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 183 KB

Absa'aet" The moao-and di-iodo derivatives of l-oxaspiro[2,5]bieyclooeta-4,7-dien-6-one, 8 and 9, reacted readily with 3,5-diiodo-L-t3,rosine at pH 8.0 to give 3,5,3'-triiodo-L-thyronine (1"3) and thyroxine in 70% and 94% yields respectively. In turn, 8 and 9 were prepared by the sodium bismuthate o