Lipids and fatty acids and their relationship to restenosis

✍ Scribed by Foley, Jerome B. ;Younger, Kate ;Foley, David ;Kinsella, Anthony ;Molloy, Martin ;Crean, Peter A. ;Gearty, Gerry ;Gibney, Michael ;Walsh, Michael J.

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 505 KB
• Volume: 25
• Category: Article
• ISSN: 0098-6569
• DOI: 10.1002/ccd.1810250106

✦ Synopsis

One hundred consecutive patients had fasting lipids and percutaneous fat biopsy performed at the time of percutaneous transluminal coronary angioplasty to determine if there was an association between restenosis and lipids or fatty acids. Anglographic follow-up and complete lipid and fatty acid results were available in 82 patients. Restenosis occurred in 37/82 (45%). Total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, and apolipoproteins A1 and B were not associated with restenosis. There was a significantly lower level of the monounsaturated fat palmitoleic acid (p < 0.02), a trend towards a lower level of the monounsaturated fat oleic acid (p < 0.09), and a trend towards a higher level of the saturated fat plamitic acid (p < 0.08) in the restenosis group. The polyunsaturated fatty acids were not associated with restenosis.

We conclude that lipids are not significantly associated with restenosis, and that lower levels of monounsaturated fatty aclds may increase the risk of restenosls.