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Lipidic peptides. IV. Penicillin and cephalosporin amide conjugates with lipidic amino acids and their oligomers

โœ Scribed by Istvan Toth; Richard A. Hughes; Peter Ward; Michael A. Baldwin; Kevin J. Welham; Andrew M. McColm; David M. Cox; Williams A. Gibbons


Book ID
113365605
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
500 KB
Volume
73
Category
Article
ISSN
0378-5173

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๐Ÿ“œ SIMILAR VOLUMES


Lipidic peptides, VII. Synthesis and str
โœ Hussain, Rohanah ;Toth, Istvan ;Gibbons, William A. ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 555 KB

## Abstract A series of ฮณโ€aminobutyric acid esters of lipidic acids, lipidic peptides and ฮณโ€aminobutyric acid amides of lipidic ฮฑโ€amino acids and oligomers were synthesised. The GABA conjugates with ester linkages (6jโ€“r) were prepared by coupling the lipidic acids and peptide conjugates to the carb

Lipidic peptides, I. Synthesis, resoluti
โœ Gibbons, William A. ;Hughes, Richard A. ;Charalambous, Mario ;Christodoulou, Mar ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 1013 KB

## Abstract The ฮฑโ€amino acids with long alkyl side chains, the soโ€called lipidic amino acids 1aโ€“e, and their homoโ€oligomers, the lipidic peptides 1pโ€“aj, represent a class of compounds which combine the structural properties of peptides and proteins with the characteristics of lipids and membranes.

Lipidic peptides. III: Lipidic amino aci
โœ R. A. Hughes; I. Toth; P. Ward; S. J. Ireland; W. A. Gibbons ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 366 KB

A series of lipidic morphine esters 1b-1f with enhanced membrane-like character were synthesized by coupling the lipidic amino acids 2a-2e to the phenolic hydroxyl group of the opioid analgesic morphine (1a). The antinocioceptive activity of the esters 1b-1f was determined in vivo following both iv