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Lipid-suppressed single-and multisection proton spectroscopic imaging of the human brain

✍ Scribed by Daniel M. Spielman; John M. Pauly; Albert Macovski; Gary H. Glover; Dieter R. Enzmann

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
976 KB
Volume
2
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Spectroscopic images of the brain have great potential in disease diagnosis and treatment monitoring. Unfortunately, interfering lipid signals from subcutaneous fat and poor water suppression due to magnetic field inhomogeneities can make such images difficult to obtain. A pulse sequence that uses inversion recovery for lipid suppression and a spectral‐spatial refocusing pulse for water suppression is introduced. In contrast to methods that eliminate fat signal by restricting the excited volume to lie completely within the brain, inversion‐recovery techniques allow imaging of an entire section without such restrictions. In addition, the spectral‐spatial pulse was designed to provide water suppression insensitive to a reasonable range of B~0~ and B~1~ inhomogeneities. Several data processing algorithms have also been developed and used in conjunction with the new pulse sequence to produce metabolite maps covering large volumes of the human brain. Images from single‐ and multisection studies demonstrate the performance of these techniques.

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