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Lipid contribution to the affinity of antigen association with specific antibodies conjugated to liposomes

โœ Scribed by Melvin E. Klegerman; Shaoling Huang; Devang Parikh; Janet Martinez; Sasha M. Demos; Hayat A. Onyuksel; David D. McPherson


Book ID
116274446
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
467 KB
Volume
1768
Category
Article
ISSN
0005-2736

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Doxorubicin (adriamycin), once considered the treatment of choice for hepatocellular carcinoma (HCC), is known to cause cardiotoxicity and myelotoxicity. To reduce the systemic toxicity of adriamycin by direct delivery of the drug to the tumor site, we established a panel of monoclonal antibodies (M