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Specific targeting of adriamycin conjugates with monoclonal antibodies to hepatoma associated antigens to intrahepatic tumors in athymic mice

✍ Scribed by Ruth Adler; Esther Hurwitz; Jack R. Wands; Michael Sela; Daniel Shouval


Book ID
119155937
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
733 KB
Volume
22
Category
Article
ISSN
0270-9139

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Specific targeting of adriamycin conjuga
✍ Ruth Adler; Esther Hurwitz; Jack R. Wands; Michael Sela; Daniel Shouval πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 741 KB

Doxorubicin (adriamycin), once considered the treatment of choice for hepatocellular carcinoma (HCC), is known to cause cardiotoxicity and myelotoxicity. To reduce the systemic toxicity of adriamycin by direct delivery of the drug to the tumor site, we established a panel of monoclonal antibodies (M