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Lipase-catalyzed transesterification as a practical route to homochiral syn-1,2-diols. The synthesis of the taxol side chain

โœ Scribed by Donghyun Lee; Mahn-Joo Kim


Book ID
104258925
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
194 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


syn-2,3-Dihydoxy-3-phenyl-propanoic acid methyl ester (la) and its simple derivatives (lb-e) are efficiently resolved in LPS-catalyzed transesterification, leading to the synthesis of the taxol side chain and analogs from both resolved enantiomers.


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