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Lipase-catalyzed resolution of 1-chloro-3-[(4-morpholin-4-yl-1,2,5-thiadiazole-3-yl)oxy]propan-2-ol: Synthesis of (R)- and (S)-timolol

โœ Scribed by Ahmed Kamal; Tadiparthi Krishnaji; M. Naseer A. Khan


Book ID
113804294
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
202 KB
Volume
54
Category
Article
ISSN
1381-1177

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A method for the synthesis of heterecyclic ring conjugates containing 1,2,3-thiadiazole and 1,2,3-triazole nuclei was elaborated. The mechanism of rearrangement (effect of substituents and solvents) was investigated by NMR spectroscopy. A novel domino-type rearrangement involving both heterocycles w