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Lipase-catalyzed preparation of chromomycin A3 analogues and biological evaluation for anticancer activity

✍ Scribed by Javier González-Sabín; Luz Elena Núñez; Nuria Menéndez; Alfredo F. Braña; Carmen Méndez; José A. Salas; Vicente Gotor; Francisco Morís


Book ID
116318557
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
445 KB
Volume
22
Category
Article
ISSN
0960-894X

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Three types of novel triptolide analogues with 9,11-olefin (3-5), five-membered unsaturated lactam ring (6-7) or A/B cis ring junction (8-14) were synthesized. Although with 9,11-olefin instead of 9,11-β-epoxide, compound 4a was much more active than the parent natural triptolide (1) with the lowest