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Synthesis, structure–activity relationship and biological evaluation of anticancer activity for novel N-substituted sophoridinic acid derivatives

✍ Scribed by Xin Li; Wu-Li Zhao; Jian-Dong Jiang; Kai-Huan Ren; Na-Na Du; Yang-Biao Li; Yan-Xiang Wang; Chong-Wen Bi; Rong-Guang Shao; Dan-Qing Song


Book ID
113495971
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
518 KB
Volume
21
Category
Article
ISSN
0960-894X

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Synthesis and biological evaluation of n
✍ Bing Zhou; Zehong Miao; Gang Deng; Jian Ding; Yaxi Yang; Huijin Feng; Yuanchao L 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 672 KB

Three types of novel triptolide analogues with 9,11-olefin (3-5), five-membered unsaturated lactam ring (6-7) or A/B cis ring junction (8-14) were synthesized. Although with 9,11-olefin instead of 9,11-β-epoxide, compound 4a was much more active than the parent natural triptolide (1) with the lowest