Lipase-catalyzed kinetic resolution of 3
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Sadao Tsuboi; Nobuyuki Yamafuji; Masanori Utaka
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Article
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1997
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Elsevier Science
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English
โ 289 KB
Reduction of 3-chloro-2-oxoalkanoates 1 with NaBH4 gave predominantly syn-3-chloro-2-hydroxyalkanoates 2 (synlanti=9119-9911) in 50--97% yields. Resolution of syn-2 by lipase-catalyzed transesterification gave (2S,3S)-2 and (2R,3R)-2-acetoxy-3chloroalkanoates (2R,3R)-3. Total synthesis of (-)-dispar