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Linkage to bipolar disorder to chromosome 18 DNA markers

โœ Scribed by Berrettini, W


Book ID
110058825
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
51 KB
Volume
2
Category
Article
ISSN
1359-4184

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Evidence consistent with the existence of genetic linkage between bipolar disorder and three regions on chromosome 18, the pericentromeric region, 18q21, and 18q22-q23 have been reported. Some analyses indicated greater evidence for linkage in pedigrees in which paternal transmission of disease occu

Exploring linkage of chromosome 18 marke
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The linkage reports of bipolar disease and chromosome 18 markers are controversial. We used the GAW10 data sets to further explore several observations: 1) a possible parent-of-origin effect with only 'paternal' pedigrees showing linkage; 2) the preponderance of women affected with bipolar disease,