Linkage to bipolar disorder to chromosome 18 DNA markers
โ Scribed by Berrettini, W
- Book ID
- 110058825
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 51 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1359-4184
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Evidence consistent with the existence of genetic linkage between bipolar disorder and three regions on chromosome 18, the pericentromeric region, 18q21, and 18q22-q23 have been reported. Some analyses indicated greater evidence for linkage in pedigrees in which paternal transmission of disease occu
The linkage reports of bipolar disease and chromosome 18 markers are controversial. We used the GAW10 data sets to further explore several observations: 1) a possible parent-of-origin effect with only 'paternal' pedigrees showing linkage; 2) the preponderance of women affected with bipolar disease,