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396. - Linkage studies of bipolar disorder to chromosome 18 markers

โœ Scribed by M.M. Nothen; S. Cichon; N. Craddock; M. Albus; W. Maier; D. Lichtermann; B. Weigelt; E. Franzek; R. Rietschel; J. Komer; R. Fimmers; P. Propping


Book ID
118858470
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
135 KB
Volume
39
Category
Article
ISSN
0006-3223

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Evidence consistent with the existence of genetic linkage between bipolar disorder and three regions on chromosome 18, the pericentromeric region, 18q21, and 18q22-q23 have been reported. Some analyses indicated greater evidence for linkage in pedigrees in which paternal transmission of disease occu

Exploring linkage of chromosome 18 marke
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The linkage reports of bipolar disease and chromosome 18 markers are controversial. We used the GAW10 data sets to further explore several observations: 1) a possible parent-of-origin effect with only 'paternal' pedigrees showing linkage; 2) the preponderance of women affected with bipolar disease,