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Linkage Thermodynamics of Macromolecular Interactions

✍ Scribed by Frederic M. Richards, David S. Eisenberg and Peter S. Kim (Eds.)


Publisher
Academic Press
Year
1998
Tongue
English
Leaves
485
Series
Advances in Protein Chemistry 51
Edition
1st
Category
Library

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✦ Synopsis


This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.

✦ Table of Contents


Content:
Edited by
Page iii

Copyright page
Page iv

Introduction
Pages ix-x
Enrico Di Cera, John T. Edsall

Electrostatic Contributions to Molecular Free Energies in Solution Original Research Article
Pages 1-57
Michael Schaefer, Herman W.T. Van Vlijmen, Martin Karplus

Site-Specific Analysis of Mutational Effects in Proteins Original Research Article
Pages 59-119
Enrico Di Cera

Allosteric Transitions of the Acetylcholine Receptor Original Research Article
Pages 121-184
Stuart J. Edelstein, Jean-Pierre Changeux

Deciphering the Molecular Code of Hemoglobin Allostery Original Research Article
Pages 185-253
Gary K. Ackers

Statistical Thermodynamic Linkage Between Conformational and Binding Equilibria Original Research Article
Pages 255-279
Ernesto Freire

Analysis of Effects of Salts and Uncharged Solutes on Protein and Nucleic Acid Equilibria and Processes: A Practical Guide to Recognizing and Interpreting Polyelectrolyte Effects, Hofmeister Effects, and Osmotic Effects of Salts Original Research Article
Pages 281-353
M. Thomas Record Jr., Wentao Zhang, Charles F. Anderson

Control of Protein Stability and Reactions by Weakly Interacting Cosolvents: The Simplicity of the Complicated Original Research Article
Pages 355-432
Serge N. Timasheff

Author Index
Pages 433-451

Subject Index
Pages 453-473


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