Linkage study of the glucagon receptor gene with type 2 diabetes mellitus in Italians
β Scribed by Claudio Gragnoli; Edrice Milord; Joel Francis Habener
- Book ID
- 116747024
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 74 KB
- Volume
- 54
- Category
- Article
- ISSN
- 1532-8600
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Type 2 (non-insulin-dependent) diabetes is associated with the deposition of islet amyloid. The major formative peptide, islet amyloid polypeptide, has recently been characterised and an abnormality of the structure or expression of this gene is a possible candidate for the inherited component of Ty
Glucagon-like peptide-1 (GLP-1) is a hormone derived from the preproglucagon molecule that is secreted by intestinal L cells and stimulates insulin secretion from beta cells. The GLP-1 receptor is a candidate gene for diabetes mellitus, as mutations may induce the impaired insulin response that is a