๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Non-linkage of the glucagon-like peptide 1 receptor gene with maturity onset diabetes of the young

โœ Scribed by Y. Zhang; J. T. E. Cook; A. T. Hattersley; R. Firth; P. J. Saker; M. Warren-Perry; M. Stoffel; R. C. Turner

Publisher
Springer
Year
1994
Tongue
English
Weight
326 KB
Volume
37
Category
Article
ISSN
0012-186X

No coin nor oath required. For personal study only.

โœฆ Synopsis

Glucagon-like peptide-1 (GLP-1) is a hormone derived from the preproglucagon molecule that is secreted by intestinal L cells and stimulates insulin secretion from beta cells. The GLP-1 receptor is a candidate gene for diabetes mellitus, as mutations may induce the impaired insulin response that is a characteristic feature of NIDDM. To study the relationship between the GLP-1 receptor gene and NIDDM, linkage of a microsatellite polymorphism flanking the GLP-1 receptor gene with diabetes was investigated in three Caucasian families with MODY and in the nuclear families of 12 NIDDM probands. A cumulative LOD score -8.50 excludes linkage in these MODY pedigrees. A LOD score of -1.24 in the NIDDM nuclear pedigrees makes linkage improbable. Mutations in or near the GLP-1 receptor gene are unlikely to be the major cause of the inherited predisposition to NIDDM in Caucasian pedigrees, but we cannot exclude a role for this locus in a polygenic model or a major role in some pedigrees.

๐Ÿ“œ SIMILAR VOLUMES

Linkage analysis of the human insulin re
Linkage analysis of the human insulin receptor gene in Type 2 (non-insulin-dependent) diabetic families and a family with maturity onset diabetes of the young
โœ S. O'Rahilly; R. C. Trembath; P. Patel; D. J. Galton; R. C. Turner; J. S. Wainsc ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Springer ๐ŸŒ English โš– 656 KB

The possibility of linkage between the human insulin receptor gene locus and diabetes was examined in three Type 2 (non-insulin-dependent) diabetic families and one family with maturity onset diabetes of the young. Insulin receptor gene haplotypes were established using BglII, Rsal and Sstl restrict

Candidate gene studies in pedigrees with
Candidate gene studies in pedigrees with maturity-onset diabetes of the young not linked with glucokinase
โœ Y. Zhang; M. Warren-Perry; P. J. Saker; A. T. Hattersley; A. D. R. Mackie; J. D. ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Springer ๐ŸŒ English โš– 566 KB

Maturity-onset diabetes of the young (MODY) is a form of non-insulin-dependent diabetes mellitus characterised by an early age of onset and an autosomal dominant mode of inheritance. Only a proportion of cases are due to mutations in the glucokinase gene. We have studied five Caucasian MODY families

DNA insertion sequences near the insulin
DNA insertion sequences near the insulin gene are not associated with maturity-onset diabetes of young people
โœ D. Owerbach; B. Thomsen; K. Johansen; L. U. Lamm; J. Nerup ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer ๐ŸŒ English โš– 351 KB

The association between DNA insertion sequences located near the insulin gene and the dominantly inherited maturity-onset diabetes of young people was studied in a large family. The distribution of the restriction fragments was compatible with Mendelian segregation. However, no linkage was found bet

GCK and HNF1A mutations in Canadian fami
GCK and HNF1A mutations in Canadian families with maturity onset diabetes of the young (MODY)
โœ Henian Cao; Sanam Shorey; John Robinson; Daniel L. Metzger; Laura Stewart; Eliza ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 28 KB ๐Ÿ‘ 2 views

Maturity onset diabetes of the young (MODY) is a genetically heterogeneous form of type 2 diabetes that is characterized by autosomal dominant inheritance, onset in early adulthood and a primary defect in insulin secretion. Mutations in at least six genes have been shown to underlie MODY, including