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Linkage studies in familial Alzheimer's disease

Book ID: 122707640
Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 286 KB
Volume: 11
Category: Article
ISSN: 0197-4580
DOI: 10.1016/0197-4580(90)90098-K

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Evidence for linkage of the Alzheimer's gene to markers on chromosomes 19 and 2 1 was assessed using single-locus and two-locus models of inheritance. Families were divided into groups determined by their average age at onset. The youngest group produced higher lod scores for markers on chromosome 2