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Linkage of Alzheimer's disease to chromosome 21 and chromosome 19 markers: Effect of age of onset assumptions

✍ Scribed by Dr. L. R. Goldin; E. S. Gershon

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
307 KB
Volume
10
Category
Article
ISSN
0741-0395

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✦ Synopsis

Abstract

Age of onset heterogeneity in Alzheimer's disease families was modelled by allowing for different liability classes for affected individuals according to their age of onset when calculating lod scores to chromosome 21 and chromosome 19 markers. Linkage to chromosome 21 was supported in the Boston data set, and the method of age correction did not greatly change the lod scores when only affected individuals were analyzed. The location of a gene on chromosome 19 for late age of onset illness was affected by the assumptions about early onset individuals. Β© 1993 Wiley‐Liss, Inc.This article is a US Government work and, as such, is in the public domain in the United States of America.

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