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Linkage of an Alzheimer disease susceptibility locus to markers on human chromosome 21

✍ Scribed by Heston, Leonard L. ;Orr, Harry T. ;Rich, Stephen S. ;White, June A.

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 437 KB
Volume: 40
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.1320400415

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Alzheimer disease (AD) is a devastating neurodegenerative disease leading to global dementia. In addition to sporadic forms of AD, familial forms (FAD) have been recognized. Mutations in the amyloid precursor protein (APP) gene on chromosome (CHR) 21 have been shown to cause early-onset AD in a smal