As compared to classical, fixed sample size techniques, simulation studies showed that a proposed sequential sampling procedure can provide a substantial decrease (up to 50%, in some cases) in the mean sample size required for the detection of linkage between marker loci and quantitative trait loci.
Linkage between marker loci and those affecting a quantitative trait
โ Scribed by Alan Robertson
- Book ID
- 112475362
- Publisher
- Springer US
- Year
- 1973
- Tongue
- English
- Weight
- 158 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0001-8244
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
By making use of pedigree information and information on marker-genotypes of the parent and F-1 individuals crossed to form an F-2 population, it is possible to carry out a linkage analysis between marker loci and loci affecting quantitative traits in a cross between segregating parent populations t
Relative-pair methods for detection of linkage between a quantitative trait and a marker locus have been proposed by a number of authors [e.g., Haseman and Elston, Behav Genet 3-19,1972; Amos and Elston, Genet Epidemiot 349-360,19891. However, development of tests of significance that combine inform
The cost of experiments aimed at determining linkage between marker loci and quantitative trait loci (QTL) was investigated as a function of marker spacing and number of individuals scored. It was found that for a variety of experimental designs, fairly wide marker spacings (ca. 50 cM) are optimum o