Evidence consistent with the existence of genetic linkage between bipolar disorder and three regions on chromosome 18, the pericentromeric region, 18q21, and 18q22-q23 have been reported. Some analyses indicated greater evidence for linkage in pedigrees in which paternal transmission of disease occu
Linkage analysis of families with bipolar illness and chromosome 18 markers
โ Scribed by An De bruyn; Daniel Souery; Karine Mendelbaum; Julien Mendlewicz; Christine Van Broeckhoven
- Book ID
- 118857535
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 811 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0006-3223
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We find a meta-data set (715 families, up to 1,124 sib pairs) for bipolar illness to have a strong signal in a 10 cM region around D18S40, and excess paternal sharing on the q arm near marker D18S64. We describe a method for metaanalysis of microsatellite marker data using affected sib-pair (ASP) me
The linkage reports of bipolar disease and chromosome 18 markers are controversial. We used the GAW10 data sets to further explore several observations: 1) a possible parent-of-origin effect with only 'paternal' pedigrees showing linkage; 2) the preponderance of women affected with bipolar disease,