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Linkage Analysis of 49 High-Risk Families Does Not Support a Common Familial Prostate Cancer—Susceptibility Gene at 1q24-25

✍ Scribed by Richard A. McIndoe; Janet L. Stanford; Mark Gibbs; Gail P. Jarvik; Susan Brandzel; Cassandra L. Neal; Sarah Li; Jason T. Gammack; Allen A. Gay; Ellen L. Goode; Leroy Hood; Elaine A. Ostrander

Book ID: 117855069
Publisher: American Society of Human Genetics
Year: 1997
Tongue: English
Weight: 110 KB
Volume: 61
Category: Article
ISSN: 0002-9297
DOI: 10.1086/514853

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Confirmation of linkage and estimation of the proportion of families who are linked in large independent datasets is essential to understanding the significance of cancer susceptibility genes. We report here on an analysis of 150 highrisk prostate cancer families (2,176 individuals) for potential li