Linkage analysis of 150 high-risk prostate cancer families at 1q24-25

✍ Scribed by Ellen L. Goode; Janet L. Stanford; Lisa Chakrabarti; Mark Gibbs; Suzanne Kolb; Richard A. McIndoe; Valerie A. Buckley; Eugene F. Schuster; Cassandra L. Neal; Elizabeth L. Miller; Susan Brandzel; Leroy Hood; Elaine A. Ostrander; Gail P. Jarvik

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 232 KB
• Volume: 18
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/(sici)1098-2272(200003)18:3<251::aid-gepi5>3.0.co;2-x

✦ Synopsis

Confirmation of linkage and estimation of the proportion of families who are linked in large independent datasets is essential to understanding the significance of cancer susceptibility genes. We report here on an analysis of 150 highrisk prostate cancer families (2,176 individuals) for potential linkage to the HPC1 prostate cancer susceptibility locus at 1q24-25. This dataset includes 640 affected men with an average age at prostate cancer diagnosis of 66.8 years (range, 39-94), representing the largest collection of high-risk families analyzed for linkage in this region to date. Linkage to multiple 1q24-25 markers was strongly rejected for the sample as a whole (lod scores at theta = 0 ranged from -30.83 to -18.42). Assuming heterogeneity, the estimated proportion of families linked (al-