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Lingual hyperpigmentation associated with minocycline therapy

✍ Scribed by Michael A. Meyerson; Philip R. Cohen; Sharon R. Hymes

Book ID
119591129
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
992 KB
Volume
79
Category
Article
ISSN
1528-395X

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## Background and objective: Cutaneous hyperpigmentations are well-documented, but nevertheless rare side-effects of high-dose or long-term minocycline therapy. the pigmental changes, may last for years, even though therapy has been abrogated. to date, no safe and effective therapy has been describ

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## Abstract Alkaptonuria, a rare autosomal‐recessive disorder caused by mutations in the __HGD__ gene and a deficiency of homogentisate 1,2‐dioxygenase, is characterized by accumulation of homogentisic acid (HGA), ochronosis, and destruction of connective tissue resulting in joint disease. Certain