Linear and convergent approaches to 2-substituted adenosine-5′-N-alkylcarboxamides
✍ Scribed by Richard C. Foitzik; Shane M. Devine; Nicholas E. Hausler; Peter J. Scammells
- Book ID
- 108283096
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 419 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
A series of chirat 2-substituted-carbocyclic-NECA analogs was prepared in seven steps with an efficient resolution. The overall yield is good and can be applied to the other carbocyclic nucleosides. Adenosine is a potent coronary vasodilator, at first described by Drury and Szent-Gyorgyi in 1929' .
A series of phenyl-substituted N 6 -phenyladenosines and N 6 -phenyl-5′-N-ethylcarboxamidoadenosines were synthesized and tested at adenosine receptor subtypes. EC 50 values were determined for cyclic AMP production in CHO cells expressing human A 2B receptors. Binding affinities were determined for