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Limiting the location of a putative human prostate cancer tumor suppressor gene at chromosome 13q14.3

✍ Scribed by Yin, Zhengnan; Spitz, Margaret R; Babaian, Richard J; Strom, Sara S; Troncoso, Patricia; Kagan, Jacob


Book ID
110062566
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
310 KB
Volume
18
Category
Article
ISSN
0950-9232

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## Abstract Loss of heterozygosity (LOH) at chromosome 13q14 is one of the most recurrent anomalies observed in sporadic prostate tumors. This LOH is believed to unmask recessive mutations that inactivate a tumor‐suppressor gene(s) which otherwise regulates normal cell growth and suppresses abnorma