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Limited Proteolysis: DisRUPting Proteasomal Inhibition

✍ Scribed by Hoppe, Thorsten

Book ID: 125831155
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 168 KB
Volume: 24
Category: Article
ISSN: 0960-9822
DOI: 10.1016/j.cub.2014.06.056

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## Abstract The 26S proteasome degrades proteins that regulate transcription factor activation, cell cycle progression, and apoptosis. In cancer, this may allow for uncontrolled cell division, promoting tumor growth, and spread. We examined whether selective inhibition of the 26S proteasome with PS