✦ LIBER ✦

Limited effect of capsaicin in T-cell transfer colitis

✍ Scribed by Mogens H. Claesson

Book ID: 102268367
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 33 KB
Volume: 17
Category: Article
ISSN: 1078-0998
DOI: 10.1002/ibd.21789

No coin nor oath required. For personal study only.

✦ Synopsis

Two years ago we published an article in this journal showing that treatment of 7-8-week-old SCID mice with neurotoxic doses of capsaicin protected the mice against T-cell transferinduced chronic colitis for a period of 6 weeks. 1 These data are in agreement with other studies showing that neurotoxic doses of capsaicin in neonatal rats and mice protect the adult animals against dextran sulfate-induced colitis and development of spontaneous autoimmune diabetes, respectively. 2,3 Subsequently, we tried to document the colitis-protective effect of capsaicin treatment in a variety of experimental setups.

In these new studies we confirm that although 7-8-week-old SCID mice

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