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Light-Induced Formation of G-Quadruplex DNA Secondary Structures

✍ Scribed by Günter Mayer; Lenz Kröck; Vera Mikat; Marianne Engeser; Alexander Heckel

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
167 KB
Volume
6
Category
Article
ISSN
1439-4227

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✦ Synopsis

The attachment of photolabile "protecting" groups to mask the activity of biologically active compounds is commonly referred to as "caging". [1] The active molecule can be released by irradiation with the laser of a confocal microscope. The method provides exact control over the location, dose and time at which this event occurs. The strengths of this approach lie, for example, in the arbitrary choice of location where a pro-[a] Dr.

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Sequence specificity of inter- and intra
Sequence specificity of inter- and intramolecular G-quadruplex formation by human telomeric DNA
✍ Ilene M. Pedroso; Luis F. Duarte; Giscard Yanez; Kris Burkewitz; Terace M. Fletc 📂 Article 📅 2007 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 470 KB

## Abstract Human telomeric DNA consists of tandem repeats of the sequence 5′‐d(TTAGGG)‐3′. Guanine‐rich DNA, such as that seen at telomeres, forms G‐quadruplex secondary structures. Alternative forms of G‐quadruplex structures can have differential effects on activities involved in telomere mainte