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Ligand Variation in the Transferrin Family: The Crystal Structure of the H249Q Mutant of the Human Transferrin N-lobe As a Model for Iron Binding in Insect Transferrins †,‡

✍ Scribed by Baker, Heather M.; Mason, Anne B.; He, Qing-Yu; MacGillivray, Ross T. A.; Baker, Edward N.


Book ID
127388277
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
319 KB
Volume
40
Category
Article
ISSN
0006-2960

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## Abstract Transferrin (TF) is a bilobal transport protein that acquires ferric iron from the diet and holds it tightly within the cleft of each lobe (thereby preventing its hydrolysis). The iron is delivered to actively dividing cells by receptor mediated endocytosis in which diferric TF preferen