Structures of two mutants that probe the
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Baker, Heather M. ;Nurizzo, Didier ;Mason, Anne B. ;Baker, Edward N.
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Article
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2007
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International Union of Crystallography
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English
⚖ 571 KB
Iron uptake by humans depends on the ability of the serum protein transferrin (Tf) to bind iron as Fe 3+ with high affinity but reversibly. Iron release into cells occurs through receptormediated endocytosis, aided by the lower endosomal pH of about 5.5. The protonation of a hydrogen-bonded pair of