𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Crystal Structures and Iron Release Properties of Mutants (K206A and K296A) That Abolish the Dilysine Interaction in the N-Lobe of Human Transferrin †,‡

✍ Scribed by Nurizzo, Didier; Baker, Heather M.; He, Qing-Yu; MacGillivray, Ross T. A.; Mason, Anne B.; Woodworth, Robert C.; Baker, Edward N.


Book ID
125953402
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
472 KB
Volume
40
Category
Article
ISSN
0006-2960

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Structures of two mutants that probe the
✍ Baker, Heather M. ;Nurizzo, Didier ;Mason, Anne B. ;Baker, Edward N. 📂 Article 📅 2007 🏛 International Union of Crystallography 🌐 English ⚖ 571 KB

Iron uptake by humans depends on the ability of the serum protein transferrin (Tf) to bind iron as Fe 3+ with high affinity but reversibly. Iron release into cells occurs through receptormediated endocytosis, aided by the lower endosomal pH of about 5.5. The protonation of a hydrogen-bonded pair of