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Ligand recognition by the I domain-containing integrins

✍ Scribed by S. K. Dickeson; S. A. Santoro


Book ID
105759756
Publisher
Springer
Year
1998
Tongue
English
Weight
755 KB
Volume
54
Category
Article
ISSN
1420-682X

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Role of the Ξ±I domain in ligand binding
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## Abstract The I domain of integrin Ξ±E was modeled on the crystal structure of that in CD11b and mutated to produce an open (high affinity) or closed (low affinity) conformation. K562 transfectants expressing mutant Ξ±E and wild‐type Ξ²7 were tested for adhesion to E‐cadherin‐Fc. Downward displaceme