A ligand-free, copper-catalyzed cascade
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Stefan G. Koenig; John W. Dankwardt; Yanbing Liu; Hang Zhao; Surendra P. Singh
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Article
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2010
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Elsevier Science
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French
β 253 KB
A variety of indole-2-carboxylic esters are accessible in yields up to 61% through a ligand-free, coppercatalyzed reaction of a series of commercially available 2-halo aryl aldehydes with benign glycine amidoesters, including the common reagent ethyl acetamidoacetate. This one-pot, three-reaction fo