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Ligand-Free Copper-Catalyzed One-Pot Synthesis of Indole-2-carboxylic Esters

✍ Scribed by Zhu, Zhiqiang; Yuan, Jiangjun; Zhou, Yirong; Qin, Yang; Xu, Jingshi; Peng, Yiyuan


Book ID
121758442
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
357 KB
Volume
2014
Category
Article
ISSN
1434-193X

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A variety of indole-2-carboxylic esters are accessible in yields up to 61% through a ligand-free, coppercatalyzed reaction of a series of commercially available 2-halo aryl aldehydes with benign glycine amidoesters, including the common reagent ethyl acetamidoacetate. This one-pot, three-reaction fo