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Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process

✍ Scribed by Cai, Qian; Li, Zhengqiu; Wei, Jiajia; Ha, Chengyong; Pei, Duanqing; Ding, Ke


Book ID
118241030
Publisher
Royal Society of Chemistry
Year
2009
Tongue
English
Weight
578 KB
Volume
48
Category
Article
ISSN
1359-7345

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A variety of indole-2-carboxylic esters are accessible in yields up to 61% through a ligand-free, coppercatalyzed reaction of a series of commercially available 2-halo aryl aldehydes with benign glycine amidoesters, including the common reagent ethyl acetamidoacetate. This one-pot, three-reaction fo