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Ligand efficiency indices as guideposts for drug discovery

✍ Scribed by Cele Abad-Zapatero; James T. Metz


Book ID
114385008
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
122 KB
Volume
10
Category
Article
ISSN
1359-6446

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## Abstract We have previously reported the design and synthesis of ligands that stabilize Transthyretin protein (TTR) in order to obtain therapeutically active compounds for Familial Amyloid Polyneuropathy (FAP). We are hereby reporting a drug design strategy to optimize these ligands and map them