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Ligand Binding was Acquired during Evolution of Nuclear Receptors

✍ Scribed by Hector Escriva, Rachid Safi, Catherine Hänni, Marie-Claire Langlois, Pierre Saumitou-Laprade, Dominique Stehelin, André Capron, Raymond Pierce and Vincent Laudet

Book ID
123640621
Publisher
National Academy of Sciences
Year
1997
Tongue
English
Weight
998 KB
Volume
94
Category
Article
ISSN
0027-8424

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## Abstract A structure‐based comparison of the ligand‐binding domains of 35 nuclear receptors from five different subfamilies is presented. Their ligand and coactivator binding sites are characterized using knowledge‐based contact preference fields for hydrophobic and hydrophilic interactions impl