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Ligand-Based Targeting of Apoptosis in Cancer: The Potential of Recombinant Human Apoptosis Ligand 2/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (rhApo2L/TRAIL)

✍ Scribed by Ashkenazi, A.; Holland, P.; Eckhardt, S. G.

Book ID: 121432076
Publisher: American Society of Clinical Oncology
Year: 2008
Tongue: English
Weight: 375 KB
Volume: 26
Category: Article
ISSN: 0732-183X
DOI: 10.1200/JCO.2007.15.7198

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## Abstract Tumor necrosis factor (TNF) is a cytokine that mediates tumor necrosis. To date, 20 different members of the TNF super‐family and 21 different receptors have been identified. All ligands of the TNF super‐family have been found to activate transcription factor NF‐κB and c‐Jun kinase. Mem