𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Lifespans of naive, memory and effector lymphocytes

✍ Scribed by Jonathan Sprent

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
846 KB
Volume
5
Category
Article
ISSN
0952-7915

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✦ Synopsis

Typical T and B lymphocytes in the secondary lymphoid organs are long-lived cells that are selected from a large pool of short-lived precursor cells in the primary lymphoid organs. The bulk of mature T and B cells are immunologically naive and remain in interphase for prolonged periods. Contact with specific antigen causes these naive cells to proliferate rapidly and differentiate into a mixture of short-lived effector cells and long-lived memory cells. Memory cells have a rapid turnover, and the survival of these cells appears to require persistent contact with antigen.

πŸ“œ SIMILAR VOLUMES

Homing of naive, memory and effector lym
Homing of naive, memory and effector lymphocytes
✍ Charles R. Mackay πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 English βš– 711 KB

Lymphocyte subsets home in a particular manner depending on their class, state of activation and 'allegiance' to certain tissues. Naive lymphocytes home preferentially through lymphoid tissues, whereas effector and memory cells home preferentially through non-lymphoid tissues and exist as phenotypic