𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Homing of naive, memory and effector lymphocytes

✍ Scribed by Charles R. Mackay

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
711 KB
Volume
5
Category
Article
ISSN
0952-7915

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✦ Synopsis

Lymphocyte subsets home in a particular manner depending on their class, state of activation and 'allegiance' to certain tissues. Naive lymphocytes home preferentially through lymphoid tissues, whereas effector and memory cells home preferentially through non-lymphoid tissues and exist as phenotypically distinct subsets with preferential localization to gut, skin or other tissues. These migration pathways, which correlate with different functional properties of lymphocyte subsets, increase the efficiency of the immune system.

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Typical T and B lymphocytes in the secondary lymphoid organs are long-lived cells that are selected from a large pool of short-lived precursor cells in the primary lymphoid organs. The bulk of mature T and B cells are immunologically naive and remain in interphase for prolonged periods. Contact with