The p75 receptor is the founding member of the TNF receptor superfamily. Members in this receptor family share a common cysteine motif repeated two to six times that serves as the ligand binding domain. In addition, several members contain a cytoplasmic region designated the death domain. The neurot
β¦ LIBER β¦
Life and death decisions: a biological role for the p75 neurotrophin receptor
β Scribed by Miller, Freda D; Kaplan, David R
- Book ID
- 110015792
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 147 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1350-9047
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## Abstract The common neurotrophin receptor (p75^NTR^) regulates various functions in the developing and adult nervous system. Cell survival, cell death, axonal and growth cone retraction, and regulation of the cell cycle can be regulated by p75^NTR^βmediated signals following activation by either
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