Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling? : Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75NTR
✍ Scribed by Sune Skeldal; Dusan Matusica; Anders Nykjaer; Elizabeth J. Coulson
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 558 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0265-9247
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✦ Synopsis
Abstract
The common neurotrophin receptor (p75^NTR^) regulates various functions in the developing and adult nervous system. Cell survival, cell death, axonal and growth cone retraction, and regulation of the cell cycle can be regulated by p75^NTR^‐mediated signals following activation by either mature or pro‐neurotrophins and in combination with various co‐receptors, including Trk receptors and sortilin. Here, we review the known functions of p75^NTR^ by cell type, receptor‐ligand combination, and whether regulated intra‐membrane proteolysis of p75^NTR^ is required for signalling. We highlight that the generation of the intracellular domain fragment of p75^NTR^ is associated with many of the receptor functions, regardless of its ligand and co‐receptor interactions.