One of the immediate eukaryotic cellular responses to DNA breakage is the covalent post-translational modification of nuclear proteins with poly(ADP-ribose) from NAD+ as precursor, mostly catalysed by poly(ADP-ribose) polymerase-1 (PARP-1). Recently several other polypeptides have been shown to cata
โฆ LIBER โฆ
Life and Death at the Hand of Poly(ADP-Ribosyl)ation
โ Scribed by Susan Smith
- Book ID
- 117268746
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 50 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0092-8674
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## Abstract Poly(ADPโribosyl)ation is a postโtranslational modification catalyzed by the enzyme family of poly(ADPโribose) polymerases (PARPs). PARPs exhibit pleiotropic cellular functions ranging from maintenance of genomic stability and chromatin remodeling to regulation of cell death, thereby re