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Lid2 Is Required for Coordinating H3K4 and H3K9 Methylation of Heterochromatin and Euchromatin

✍ Scribed by Fei Li; Maite Huarte; Mikel Zaratiegui; Matthew W. Vaughn; Yang Shi; Rob Martienssen; W. Zacheus Cande

Book ID: 116353867
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 736 KB
Volume: 135
Category: Article
ISSN: 0092-8674
DOI: 10.1016/j.cell.2008.08.036

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## Background In the mouse zygote the paternal genome undergoes dramatic structural and epigenetic changes. Chromosomes are decondensed, protamines replaced by histones and DNA is rapidly and actively demethylated. The epigenetic asymmetry between parental genomes remains at least until the 2-cell