Library Synthesis Using 5,6,7,8-Tetrahydro-1,6-naphthyridines as Scaffolds
β Scribed by Zhou, Ya; Beeler, Aaron B.; Cho, Sanghyun; Wang, Yuehong; Franzblau, Scott G.; Snyder, John K.
- Book ID
- 126323762
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 167 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1520-4766
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## Abstract A new access to 5βphenylβ5,6,7,8βtetrahydroβ1,6βnaphthyridines **25aβ28a** (n=1) and 5βphenylβ6,7,8,9βtetrahydroβ5__H__βpyrido[3,2β__c__]azepines **25bβ28b** (n=2) has been developed by first preparing the functional pyridine moiety followed by intramolecular cyclization forming the par
An expeditious and concise synthesis of 3-(difluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridine and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines is described. Starting from N-benzyl piperidone, the key intermediates leading to these two biologically desirable synthones were rapidly as